Monthly Archives: June 2016

Improving ADR reporting habit

ADR reporting: Adverse Drug reactions are inevitable outcome of drug therapy. We can’t avoid it but we can try to mitigate it by expecting or predicting it based on the previous documented reports. Uppsala Monitoring Centre (UMC) in Sweden_WHO initiative, have provided certain guidelines and facilities to voluntarily report ADR by any health care faculty. In few countries, it is even done by patients themselves. But India lags behind reporting ADR even after setting up of National Coordination Centre by Pharmacovigilance Program of India (NCC-PvPI). The nodal body is Indian Pharmacopoeia Commision (IPC) at Ghaziabad which comes under the purview of Ministry of Health and Family Welfare, Govt. of India and works in collaboration with CDSCO, India.

Reason:

  • Being complacent
  • Lack of awareness
  • Lack of responsibility
  • Lack of sustained motivation by the nodal bodies
  • Lack of facilities

Indians have this “Chalta Hai” attitude for lot of things. If not all, many have. We just crib over lack of change but we never take steps to be a part of the movement which will bring change. Just being complacent for anything which happens to us.

This combined with lack of awareness and responsibility of such happenings do more harm than good. Many practitioners outrightly project reporting ADR is a responsibility of nurses or interns or Department of Pharmacology! Unless they intimate about an ADR, no signal can be detected! I have seen lame scenarios like physicians laughing over the reporting habit by just saying that “We will make sure ADR doesn’t happen in our wards”. Nothing more to be said. Period.

Lack of motivation by nodal bodies plays a big role in denting the reporting habits among the health care professionals. Starting PvPI program doesn’t ensue successful reporting. Previously there were many confusions like where to report, whom to contact for queries. But now IPC website mentions everything about reporting. Still just mentioning doesn’t give full flexibility in reporting. Many AMC (ADR Monitoring Centres) don’t have VigiFlow, a web-based Individual Case Safety Report (ICSR) management system that is specially designed for use by national centres in the WHO Programme for International Drug Monitoring. It is provided free of cost by WHO to report ADRs directly to UMC and to IPC. Login authorisation leads to uploading of ADRs. Many centers applied in vain and still waiting for any response from PvPI/IPC. Lack of these prime facilities still create a huge dent in reporting practices.

In many medical colleges, post graduate students walk through all the wards in the hospital to check for any ADRs, even after sensitising the practitioners and staff nurses towards reporting ADR. This “ADR collection” happens in this way even after:

  • Providing the contact numbers of the staffs of Department of Pharmacology
  • Providing the duty rosters with contact numbers of the duty PGs of department of Pharmacology
  • Providing ADR drop boxes at every wards
  • Sensitizing the clinicians at the weekly clinical meetings

So this lead to a scenario of frustration and lack of interest among the ADR “collectors”. Sometime later the whole habit of reporting vanished only to reappear when it’s mandatory requirement for some “regulatory purpose”.

As we all have become app savvy, Dr. Sachin Kuchya, Associate Professor of Pharmacology, NSCB Medical College, Jabalpur conceptualised and developed an android app, named ADR Reporting. Later he was invited by IPC / PvPI to give a presentation on the same which lead to the authorisation of the app by IPC as an official reporting app for ADRs. But a lack of clarity in the authorisation documents keeps the usage of the App under abeyance by many AMCs.

As quoted by him:

“Let me share something very relevant,this app has been my brainchild and I have invested close to (INR) 1.80 lakh plus, towards its development and updation (updating). With the help of NCC Pvpi, I could connect all the 179 AMC’s recognized till may 15, (2016) & also I could dedicate the app to the nation. Now, I don’t have money. What I wish henceforth that NCC Pvpi should take it forward. Develop even a better version, which works across all platforms, is user friendly. But again I wish to assure you all that it’s still the best way to report ADRs, let’s continue with the same. With the app based data, at least the reporter is verifiable, the paper based has everything questionable. Feel free to use the app and spread the same. Best wishes, however if you all need some assistance I am always their. Thanks and Regards.”

IMPAS.in appreciates Dr.Sachin Kuchya’s effort in developing and dedicating this app. We have few suggestions to improve the reporting habit through an app, either by this ADR Reporting app or by any third party app authorised by the Indian government. ( Note: Many Big Pharma have their own ADR reporting app developed for their own purpose and also a paid version for third party use)

  • Release the official authorisation document of the app by IPC in their website
  • Gov. of India should invite the cellular companies, as a part of their Corporate Social Responsibility (CSR) to provide free data usage for these apps which will promote the usage and reporting irrespective of the reporters data balance.
  • Go a level up and provide a smart phone, with inbuilt  authorised app for ADR reporting, used only for this purpose. Keep this in all the wards of the hospital. If it is made as a mandatory requirement for MCI recognition, all the colleges will be obliged to have this

But this app reporting is not the only solution. We as a healthcare faculty should have a moral responsibility of reporting any ADR. Even it’s a trifle reaction like itching or sneezing, it has to be reported as the severity varies between patients. and the responsibility of reporting has to be extended from the hands of department of Pharmacology to the clinical departments.

Recently we saw a spurt in the promotional activities of ADR reporting by NCC\PvPI. They have also started a WhatsApp group for discussion and promotional activities for ADR reporting. Send a request to #7042343309 to join the group.

India is moving towards a healthy ADR reporting practices. But this movement is in a snail pace. It needs to be speeded up and let’s all work towards it!

Also, recently IPC has initiated Hemovigilance program of India (HvPI) as an important tool for improving safe blood transfusion practices in a country. It is a set of surveillance procedures covering the whole transfusion chain from  the collection of blood and its components to the follow-up of its recipients intended to collect and assess information on unexpected or undesirable effects resulting from the therapeutic use of labile blood products and to prevent their occurrence and recurrence. In this program the blood banks has to be registered under HvPI and after which a username / password is provided to report the adverse events in the portal provided within the webpage. Click here to view HemoVigil. There is also a similar portal named DonorVigil.

IPC have also started Materiovigilance Programme of India (MvPI) to monitor the safety of medical devices in the country.

Useful Links:

ADR Reporting App: https://play.google.com/store/apps/details?id=sADRReporting.sADRReporting

ADR reporting form: http://www.cdsco.nic.in/writereaddata/ADR%20form%20PvPI.pdf

Medicinal Side Effects Reporting form_ENGLISH: (also available in major regional languages)  http://ipc.nic.in/writereaddata/mainlinkFile/File262.pdf

Transfusion Reaction Reporting Form: http://nib.gov.in/Haemovigilance/TRRF_Form.pdf

Also, check out this article written by Ashish Jain and Ravneet Kaur on “Hemovigilance and blood safety”, published in Asian Journal of Transfusion Science. Read this article hereJain A, Kaur R. Hemovigilance and blood safety. Asian Journal of Transfusion Science. 2012;6(2):137-138. doi:10.4103/0973-6247.98911.

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Indian Pharmacovigilance Day Conference | Mumbai | July 29,2016

IMG-20160629-WA0000

Click here for registrations.

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World Congress of Basic and Clinical Pharmacology (WCP-2014) | “My experience at Cape Town” | Dr.Natesh Prabhu

WCP: World Cup for Pharmacologists, that’s how they called it as it happens once in four years. I was so happy when I received the mail mentioning the acceptance of my bursary application. This time I was even happier than when I received the abstract acceptance mail.

Happy moment

Happy moment

I was too excited to attend the conference after receiving my visa just a day before the departure date. It was a race and with God’s grace I was all aboard. I met the representatives of Indian Pharmacological Society (IPS) at Mumbai airport. As IPS is the member society of IUPHAR, it gets to participate in voting bid to select the next organizers for subsequent two congresses. And it happened to be Japan for WCP-2018 and Scotland for WCP-2022.

So I was all set for a night long flight. I couldn’t control my excitement. It was like a dream moment. I was the youngest among my pharmacology team, 27 years old then, single and travelling to Cape Town 😉 I had the opportunity to meet and spend time with Dr.Y.K Gupta, Dr. Bikash Medhi, Dr.Surender Singh, Dr.Arunabha Ray, Dr.Kavita Gulati, Dr.Dinesh Kumar, Dr.Dinesh Badyal, Dr.Chetna desai, Dr.Anil Gulati and many others. We landed in Johannesburg and during my transit form Johannesburg to Cape Town, I befriended a Chinese co-passenger, Maggie Yiqun He, whose mom was an attendee of the conference and came to know about the Chinese working culture. We are still in touch through Facebook.

Maggie Yiqun He

Maggie Yiqun He

Touchdown Cape Town and I had already started my City Tour which was briefed by a cabbie who was too cool to tell about few secrets of downtown!

Cabbie

Cool Cabbie

Day O-Sunday, event kick started by evening with traditional opening ceremonial dances and inaugural speeches which ended with a gala dinner. The next five days were filled with lectures from various eminent speakers among them I had a chance to interact with a guest speaker from Sydney as we were walking from our hotel to the Convention Centre where the conference was held. I learned about the role of pharmacologists in health services in Australia.

Day 1, I was recording the beautiful streets of Cape Town as I walked to the Convention Centre. I got my bursary of Zar 3,000 from the registration desk along with conference goodies and ID. I was behaving too mature among those experienced attendees. Sometime later I got to meet people of my age from other countries, both Indians and foreigners.

During the five day event, I got to listen to few brilliant lectures. Also few presentations were so pathetic that the speakers were just reading from the slides and one among them couldn’t even read the contents properly. Then I was told that few “influential” guest speakers somehow “convince” the organizers to include them as a speaker-Lee side of an International Event.

Day 2, I did two poster presentations on diabetes and during the presenting period I had a chance to meet various researchers from USA, Malaysia, Kenya, South Africa and Japan which gave me a good perspective about the research culture over there. IPS team was invited by IUPHAR for a cocktail dinner with other member societies. I too got the invite from IPS to attend the dinner for which I am thankful to them. I had a great opportunity to talk to the presidents of various societies in other countries which gave me an inspiration to start Indian Medical Pharmacologists Association (IMPA).

Day 3, I attended the conference till noon and shared a cab with two others for the peninsular tour of Cape Town. The chauffeur was too cool to converse with and guided me to the nightlife of Cape Town and I must say it’s a Maverick world out there! 😉

Day 4, usual type of presentations among which two lectures on Pharmacogenetics impressed me. Later that night, I was invited for the dinner hosted by Dr.Y.K.Gupta and Dr. Anil Gulati at Hotel Hilton. We all had a scrumptious meal and nice chat which ended with a photo session.

Day 5, I was already experiencing the blues of leaving Cape Town. As it was a half-day session, I started my vagabond journey by foot to explore the city only to return to my room by night and had Gnocchi, an Italian delicacy which was introduced to me by a Pakistani whom I befriended at the hotel. We used to meet at the lobby and have a chat over a beer by night.

IMG_0231

Pakistani Pal

Next day early in the morning, I left Cape Town with happy memories and wonderful experiences from my first international conference. Deep in my mind I had this thought of bringing a change to the stagnant pharmacology scene in India and till now I am trying my level best to make a mark!

And about the tips on tapping the bursaries: “Motivation Letter”

  • Express your true intention in the bursary application.
  • The area of your research should preferably be of social importance.
  • Project that you are in financial needs for attending the conference.
  • Convince them that attending the conference will bring a change in your future endeavors.
  • And don’t fail to repeatedly write to them, even if they deny your application on first attempt.
  • Being a student and also an Indian will give you an extra edge over the other applicants.
  • A good English knowledge will be helpful to write the “Motivation Letter” for the bursary application within the given word limit.

    My Motivation Letter for Bursary Application

    My Motivation Letter for Bursary Application

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World Congress of Basic and Clinical Pharmacology 2018 | July 1 – 6 | Japan

The 18th World Congress of Basic and Clinical Pharmacology, titled “Pharmacology for the Future” will be held at Kyoto International Conference Centre, Kyoto, Japan.

First WCP was held at Stockholm, Sweden in 1961. IUPHAR congresses are hosted by IUPHAR member societies. The location of each future congress is determined eight years in advance by a vote of the delegates, selected by the IUPHAR member societies, during the General Assembly held every four years in conjunction with a congress. Thereby the next congress, WCP-2022 will be held at Glasgow, Scotland, UK. Also not to forget that Indian Pharmacological Society is a member of IUPHAR.

I had attended the previous congress, WCP-2014 held at Cape Town, South Africa and IUPHAR acknowledged my research work on diabetes and sponsored me bursaries of Zar.3000 (worth INR 18,000 then) and made my conference registration completely free (worth of INR 30,000 | Zar.5000). I owe this to my alma mater, Kasturba Medical College, Manipal University, Mangalore and to my mentors Dr. Sheetal Ullal and Dr. Ashok Shenoy. In my next post, I will share my experiences at WCP-2014 and will also give you few tips on tapping the bursaries. So do follow us!

WCP-2014 with IPS team

WCP-2014 with IPS team

 

 

 

 

 

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IMPAS.in – Exclusive Interview with previous year winners of International BioCamp_2015 ¦ Dr.Manthan Mehta

Yesterday we gave you Dr.Pavithra Krishnan‘s interview. Join us today for the interview with Dr.Manthan Mehta (Arrow marked in the pic) who too made it to Basel, Switzerland.

What is biocamp and how did you come to know about it?

BioCamp is a biotechnology leadership camp organized by Novartis which brings together 50 participants from the fields of medicine, pharmacy, life sciences, management, patent law etc. It consists of sessions on drug development, gives an insight into the pharmaceutical industry and a competition based on a given case study. I got to know about it from BusinessLine, a leading Business newspaper and through the IMPA Clinical Pharmacology group (WhatsApp).

Explain about the selection process:Road to Hyderabad

It’s a three step process.

Step 1: Application form which consisted of personal information and academic credentials.

Step 2: Aptitude Test. A 40 minute online test consisting of 20 questions on Logic and 20 questions on English language.

Step 3: Once you clear the Aptitude test successfully, you have to upload your CV and degree certificates. Following which is a telephonic Interview which decides your final selection for the BioCamp.

Tell us about the Preliminary online test? How will you score the difficulty on a scale of 0-5 (0 – Easy | 5 – Insane)?

The preliminary online test is fairly easy. I would rate it 2 on a scale of 5.

Tip: You just have to be quick!

Did you prepare for the telephonic interview? Give few tips on this for our readers.

The telephonic interview is the most crucial part of the selection process. I did not prepare for it per se.

Few tips for the interview would be:

  1. Please be honest.
  2. Be spontaneous and to the point.
  3. You get sufficient time to showcase yourself.  According to me, how you answer a question is more important than what you answer.

What kind of questions were asked in the telephonic interview and on what topics were they?

The questions ranged from your thesis topic to extracurricular activities. There is a special emphasis on past experience in working in a team or a group. The questions test your goals and ambitions in life and also check your core values. For example: What inspired you to take up MD Pharmacology over a clinical branch?, What career path do you intend to choose after your MD?, Etc.

How was your state of mind after the interview? Did you feel positive or doubtful?

I thought I answered the questions to the best of my ability but that element of doubt was always there!

How helpful was your college in this achievement?

TNMC played a major role in this achievement. We have an interesting pattern of holding journal clubs as a group activity and that helped me a lot when it came to working in a group at the BioCamp. Exercises on protocol designing and biostatistics helped me in solving the case study well. A special thanks to the Department of Pharmacology, TNMC.

Was the “Mumbai Edge” helpful?

They choose people from all over the country irrespective of the city/place they belong to.

What were your preparations after getting selected for the National BioCamp?

You can’t prepare anything since you don’t know what case study is going to come your way. They sent us some pre-reading material which I read before attending.

Where there any bursaries from Novartis?

The whole BioCamp was sponsored by Novartis and they gave us some amazing goodies too.

How were the accommodation and other arrangements?

The arrangements were fabulous. They pampered us a lot.

A detailed walk through at Novartis, Hyderabad_BioCamp.

Day 0 : A brief orientation followed by division into teams for an interesting treasure hunt through the sightseeing places in Hyderabad. A very innovative concept. In the evening, we had a small self-learning exercise which helped us identify our basic personality traits. It was followed by a DJ party!

Day 1 : Starts sharp at 8. ( Very particular about time). Some keynote sessions by great speakers followed by the case study question in the evening. New teams were formed and 2 facilitators were appointed for each team. The whole night was a brainstorming session.

Day 2 : I was too sleepy to sit through the sessions but they were pretty interesting and kept me awake. Case study discussion continued through the evening and night.

Day 3 : D-day. All the teams presented the case study which was judged by a panel of 7 judges from diverse backgrounds. A Question & Answer session followed. (You can answer just one question). A grand valedictory function ended the BioCamp.

Was there any bitter moments at BioCamp?

The whole experience was amazing. There wasn’t any place for bitter moments.

How competitive were the other teams?

Very competitive. Each one was better than the other. You have to give better than your best.

I have heard from previous BioCamp participants that, there will hardly be time to sleep at night. How did you pass through this drill?

That’s true. But you don’t realize where the night passes. You will be too active that you lose your ( Day-Night) time-orientation.

Did attending BioCamp bring about any change in your career goals?

It made me more focused about my career goals. I understood closely how the industry functions and what role suited me best.

In what way do you think BioCamp will be helpful in sculpting your future?

BioCamp grooms your personality as a whole. It helped me in understanding team-play and respecting everyone for what they are. It has made me more responsible as an individual.

 What are you planning to pursue after your MD?

I am planning to pursue a career in the industry as a part of the Medical Affairs team.

After attending Biocamp, what is your say on Current Scenario of Big Pharma in India?

Big Pharma has a big role in India. Novartis, for example, has a global development centre in Hyderabad. There is immense growth in Big Pharma and India has always been a country of interest for the world.

What personalities in you have helped you to succeed in this workshop?

The judges, facilitators and my team-mates could answer that better. In my view, my patient hearing and social skills helped me a lot.

 If you want to re-experience a moment at Hyderabad, what will be that?

The moment when my name was announced as a winner. I just didn’t know how to react.

Where you determined to get selected for Basel or just went to attend the National BioCamp and eventually got selected?

At the back of our mind, we always try to win. But to be honest, my main goal was to learn at the BioCamp. Getting selected for Basel was the best reward I could expect.

What are you expecting at Basel? (We asked this before she started to Basel)

A whole lot of fun-filled learning, networking and an experience of a lifetime.

How helpful was our WhatsApp/Telegram group?

It was extremely helpful. The Clinical Pharmacology discussions helped me devise a good clinical development strategy for my case-study. IMPA should continue its efforts in imparting knowledge to budding pharmacologists like myself.

Any suggestions for the future participants of BioCamp?

Everyone must try. Winning is not the only thing. What we learn there cannot be put on paper. It’s an experience you must live for yourself. I had explained the selection process and the whole functioning of the BioCamp. The knowledge you gain at your college gets applied there, so one must be proactive at the institute level as well. In case, people want to know more, I am always happy to help. Feel free to get in touch with me.


Dr.Manthan Mehta is a 3rd year postgraduate student pursuing MD Pharmacology at Topiwala National Medical College & BYL Nair Hospital, Mumbai. His (career) goal is to make it big in the pharmaceutical industry and he has been striving hard towards it. As quoted by him: “I am a funny sarcastic guy who tries to have fun in whatever I do.”

We are happy to have him interviewed and soon will be presenting you all about his experience at International BioCamp held at Novartis Global HQ, Basel, Switzerland.

Dr.Manthan (Encircled) with his team mates at Hyderabad

Dr.Manthan (Encircled) with his team mates at Hyderabad

 

 

 

 

 

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Drug and Cosmetic bill update

1. Govt. of India has decided to withdraw UPA bill 2013 (one which talks about penalties).
2. There will be separate legislations on medical device and drugs and cosmetics.
3. The bill on medical device will be notified shortly.
4. New draft bills on drugs and cosmetics will be notified by 2-3 months. There can be a fresh look at penalties for companies violating manufacturing and clinical trial guidelines

Courtesy: Dr. Maulik Doshi

Read about Drugs and Cosmetic Act, 1940 here.


Dr. Maulik Doshi, who had completed his MD and DM in Clinical Pharmacology at Seth GS Medical College and KEM hospital_Mumbai, is working as a Manager in Sun Pharmaceutical, Mumbai. IMPAS.in acknowledges his passion towards teaching clinical pharmacology and keen interests on updating & sharing information to all.

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British Pharmacological Society (BPS) Conference | 13-15 December,2016_ London

The annual meeting of British Pharmacological Society (BPS) for 2016 | Pharmacology 2016 will be conducted between 13-15 December,2016 at Queen Elizabeth II Centre, London, UK. The guest societies which will be hosting the programme along with BPS are:

  • The American Society for Clinical Pharmacology and Therapeutics
  • The American Society for Pharmacology and Experimental Therapeutics
  • The Chinese Pharmacological Society

The registrations and abstract submissions will be commencing from June 24th onwards (most probably). Have a glance at the drafted program here.

On December 12th, BPS have planned for a satellite session on “Shaping the Future of Pharmacology” exclusively for UGs, PGs, PhDs and PDFs in Pharmacology.  As it’s limited to 100 participants, make sure you register your slot early if you are interested.  Get an overview of the programme here.

Also check out other future events here.


Dr.Rohit Kodagali and Dr.Rachana Menon, attended the BPS-2014 during their post graduation period and represented IMPA. We will be giving you an exclusive interview on their experience of getting selected and attending BPS-2014.

Dr.Rohit Kodagali M.D, graduated from Christian Medical College (CMC), Vellore, is currently working as Assistant Manager Medical Services at Boehringer Ingelheim, Mumbai.

Dr.Rachana Menon M.D, graduated from M.S.Ramaiah Medical College, Bangalore, got seleted to pursue a full time M.Sc in Drug Development Science at King’s College London, which will be commencing from this September.

Dr.Rohit and Dr.Rachana at BPS,2014

Dr.Rohit and Dr.Rachana at BPS-2014

 

 

 

 

 

 

 

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IMPAS.in – Exclusive Interview with previous year winners of International BioCamp_2015 ¦ Dr.Pavithra Krishnan

Dr.Pavithra Krishnan with Mr.Ranjith Shahani, the Managing director and VC of Novartis, India.

As the participants of National BioCamp_Hyderabad,2016 have been announced, we present you our exclusive interview with previous year National BioCamp winners, Dr.Pavithra Krishnan and Dr.Manthan Mehta who made it to Basel, Switzerland.

To begin with, read what Dr.Pavithra Krishnan had told us!

What is biocamp and how did you come to know about it?

Biocamp is a four day event hosted by Novartis. It’s a platform where we get to meet great minds from different parts iof the country and their role in the pharmaceutical sector. I would simply  call it “a unique learning experience” and an opportunity to meet the who’s who of the pharma world.

I was introduced to it by my colleagues who had applied for the same last year.

Explain about the selection process:Road to Hyderabad

The selection process is rigorous. There are three steps to get there.

Step 1: A strong and impressive CV will help you get through step one. Extracurricular activities has also been given weightage apart from our academics which I believe gave me the edge over others.

Step 2: The aptitude test which is easy to crack if you know basic math(ematics) and good english.

Step 3: The telephonic interview where they assessed our overall personality.

Tell us about the Preliminary online test? How will you score the difficulty on a scale of 0-5 (0 – Easy | 5 – Insane)?

I would score it 0 because maths is my favourite subject. So I didn’t have any trouble.

Did you prepare for the telephonic interview? Give few tips on this for our readers.

No. I did not prepare for the interview. I had a few really nice seniors who gave me an idea of what to expect during the interview. Since it had nothing to do with our textbooks I did not prepare(for it).

What kind of questions were asked in the telephonic interview and on what topics were they?

It was not completely academic based. Apart from my thesis discussion and bioassay ,there was  personality assessment. Which included our interests, hobbies and leadership qualities, tackling with hypothetical life situations at work and elsewhere, to mention a few.

How was your state of mind after the interview? Did you feel positive or doubtful?

Very positive. I knew I had made it.

How helpful was your college in this achievement?

My HOD and staff have always been very supportive and encouraging. There have never been problems getting permission to attend such events. I was given my space to prepare.

What were your preparations after getting selected for the National BioCamp?

After getting selected I read up the pre reads that’s given to every selected participant. My friend, Dr.Divyalasya (Previous year participant of National BioCamp) from KIMS Bangalore, gave me an overview of how exactly things work there. I could then know which part of pharmacology I had to focus on. My brother Chaitanya, who gave me tips on management aspects. I believe that a medico with a fair amount of knowledge in Marketing (Yes, I read a few books) is likely to have an advantage.

Where there any bursaries from Novartis?

All our travel and accommodation and food was sponsored by Novartis.

How were the accommodation and other arrangements?

Beyond awesome!

A detailed walk through at Novartis, Hyderabad_BioCamp.

Day 0: Ice breaker.If you are an extrovert and love socializing this is your  day.And you get to roam  the beautiful city of Hyderabad.

Day 1: Talks and sessions focused on Clinical pharmacology.

Day 2: Talks and sessions focused on Management.

Day 3: Presentation of the case study and gala dinner.

 

Was there any bitter moments at BioCamp?

No. Not one.

How competitive were the other teams?

Extraordinary would be the appropriate word. Each and every team worked passionately in the task assigned and it showed on the last day of team presentations.

I have heard from previous BioCamp participants that, there will hardly be time to sleep at night. How did you pass through this drill?

It depends on your teammates and how well you can pull it off in the end. Our team had more than enough sleep on day 2 and we compensated by being awake for a long time on the night before our presentation. It wasn’t bad at all because we were having fun while we were at work.

How challenging it was being a female participant?

Well, I think gender never posed any challenge. In fact we have performed better. Two ladies out of top three.

Did attending BioCamp bring about any change in your career goals?

No change. Post Biocamp, I am only surer of where I am heading. It’s all clear now.

In what way do you think BioCamp will be helpful in sculpting your future?

The diversity that I was exposed to in the three days was mindblowing. I could easily identify my strengths and weaknesses. On what I have to work on urgently. The contacts of course will come a long way. I made some amazing friends for a lifetime!

 What are you planning to pursue after your MD?

May be after the Swiss trip I will be surer of which course to take up. Currently Industry.

After attending Biocamp, what is your say on Current Scenario of Big Pharma in India?

The future is bright and I am very optimistic about that.

What personalities in you have helped you to succeed in this workshop?

                                             ~Skipped~

 If you want to re-experience a moment at Hyderabad, what will be that?

The Ice breaker session with my team and of course, the winning moment.

Where you determined to get selected for Basel or just went to attend the National BioCamp and eventually got selected?

I was determined to fly to Basel, just like everyone else. But not winning did not mean disappointment. I take everything in life as a “bonus”.

What are you expecting at Basel? (We asked this before she started to Basel)

Friends. Learning. Fun. (In that order)

How helpful was our WhatsApp/Telegram group?

IMPA is a great initiative for students like us. The timely clinical updates have been of immense help. Clinical Pharmac discussion inspired me to read and learn more about its various dimensions that came in handy during this Biocamp. Thanks to you Dr.Natesh Prabhu (Admin and Chief Editor of impas.in).


Dr.Pavithra Krishnan is a student of Rajarajeswari Medical College and Hospital,Bangalore, Karnataka. She had worked as a  Research Intern in a Clinical Research Organisation during her post graduation period. Also she is a trained classical dancer who loves art and music apart from reading and travelling and strongly believes  that versatility makes life more adaptable and colourful.

We are happy to have her interviewed and soon will be presenting you all about her experience at International BioCamp held at Novartis Global HQ, Basel, Switzerland.

Dr.Pavithra with her team at Hyderabad

Dr.Pavithra with her team at Hyderabad

 

 

 

 

 

 

 

 

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“Risk Based Inspection” by DCGI made the Pharma Biggies to land up in a soup

Risk Based Inspection” by the Indian drug regulator, DCGI brought the pharma biggies under limelight, but for a wrong reason. Pharma majors like Cipla , Pfizer are being inspected for allegedly selling poor quality medicines and noncompliance to manufacturing norms.

This is a first of such kind of inspection, where 200 companies are being inspected among which 36 from Tamil nadu, Maharashtra, Uttarakhand and Himachal Pradesh have been inspected.

This is not the first time that these biggies are coming under the lens of a drug regulator. Last year Sun Pharma and Dr.Reddy’s were among 7 companies for which US-FDA issued a warning letter on concerns for poor manufacturing practices. Read more about this news here.

Last year Govt. of India had framed few regulatory pathway to assist pharma companies mainly to facilitate speedy approvals, while bringing in transparency, accountability and predictability.

Also read about US-FDA risk based inspections herehere…& here.

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Conference on Medication Management & Use | 6&7,October 2016, SriRamachandra Medical College, Chennai

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A Statin Affair | Refuting the controversies surrounding the statin use

Recently there is lot of air surrounding the statin usage. Few sites and even FB posts by the doctors claims that statins are harmful and upon seeing that the users, mostly patients asks the doctor whether to continue the drug or not? This created a lot of confusion among the patients. Once a doctor prescribes statin they are being questioned about fidelity of its use. Upon seeing all those we at impas.in wanted to disprove all such claims backed with evidence. Watch this video presentation below.

 

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Workshop on Statistical Methods in Medical Research and Introduction to SPSS | NIMHANS | 14-16 July,2016

Department of Biostatistics, NIMHANS will be conducting a workshop on Biostatistics and SPSS. The cost of the workshop is Rs:4,000 (Breakfast,Lunch, Refreshments and Course materials). Limited in-campus guesthouse accommodations are available for extra payment. The program will be from 9 AM-5  PM and it’s restricted to 50 participants on first come-first serve basis. Get the workshop brochure here and the registration form here.

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Cipla – Nacimbio tag upfor HIV/HepB drug innovation & Manufacturing

Cipla tied up with a Russian major_ Nacimbio to collaborate on HIV and Hepatitis C drugs.The companies have inked a Memorandum of Understanding on innovative antiviral medical products for HIV and Hepatitis C treatment and on technology transfer and active pharmaceutical ingredients (API) manufacturing.

Read more about it here.

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A different way to tackle obesity | AspireAssist

AspireAssist | Anti-Obesity device which drains part of the stomach, after a meal, directly into the toilet thereby controlling the calorie intake (30% reduction)! See the video about how to set it up.

Read more about the US FDA aprroval statement here.

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Artificial Intelligence for dispensing medications!!

Aster Medcity, Kochi_Kerala, owned & managed by Dubai based healthcare conglomerate-Aster DM Healthcare| Founded by Mr. Azad Moopen, installs a Robot developed by a German based company named Rowa Smart Systems and says that this method can reduce the waiting time at the pharmacy.Read more about this here.

This hospital also had installed da Vinci surgical system for Minimal Access Robotic Surgery (MARS).

Laproscopic_Surgery_Robot

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IPSCON -2016 | October 20-23, 2016 | PGIMER, Chandigarh

The 49th annual conference of Indian Pharmacological Society will be organised and conducted at PGIMER, Chandigarh under the chairmanship of Prof. Y.K. Gupta, Professor & Head, Department of Pharmacology, AIIMS, New Delhi, Organizing Secretary Prof. Bikash MedhiProfessor Department of Pharmacology, PGIMER, Chandigarh and co-organizing secretary Prof. S S Sharma, NIPER, Mohali, Punjab. 

IPSCON-2016, will be enriched with various scientific sessions, that cover current issues of regulatory, industrial and academic modern pharmacology such as safe and effective therapy, antibiotic resistance, Good Clinical Practice and Bioethics, Pharmacovigilance, Pharmacogenomics’ in addition to the recent avenues on molecular pharmacology research and impending challenges. Medication safety, recent regulatory changes, Pharmacovigilance, Nanomedicines, stem cell, recent advances in therapeutics, Current status of medical education to name some of them.

 Objectives of IPSCON -2016

  • Regulatory point of view
  • National and International collaboration
  • Industry and academia collaboration
  • International prospects of Pharmacology
  • Current curriculum and future prospects in Basics and clinical Pharmacology.

Early bird Online registrations ends by June 30,2016. For further information, please visit IPSCON-2016 Website.

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Wearable Artificial Kidney (WAK)

Imagine how easy it would be to get a dialysis on the move. Now read about wearable artificial kidney (WAK) below.

This WAK provides a most ergonomic alternative for a patient undergoing dialysis for End Stage Renal disease (ESRD). The patient can be mobile while they are having a dialysis session.

wearable_artificial_kidneyWatch Full Movie Online Streaming Online and Download

Dr. Victor Gura, a physician specializing in internal medicine and kidney disease and a clinical associate professor at the David Geffen School of Medicine at UCLA., created the initial prototypes for the WAK in his clinic in Beverly Hills, California. He completed the prototypes in a lab at Cedars-Sinai Hospital in Los Angeles. His original team included the late Austrian physicist and equipment safety standards developer Hans Dietrich Polachegg, as well as bioengineer Masoud Beizai, and physician and medical device researcher Carlos Ezon, both of whom live in Los Angeles.65144_1_kidney_gura_220

And now the results of an exploratory clinical trial indicate that a wearable artificial kidney could be developed as a viable, new dialysis technology.  Some redesigns would be required to overcome device-related, technical problems observed during the testing.

The main concern with the dialysis was pure water which as much as half a litre is used every 5 mins. But with this WAK, just half a litre is used up which is purified and reused. Though the device looks bulkier this just give us a new ray of hope for such futuristic alternatives.

Meanwhile check out this video about WAK in which Dr.Jonathan Himmelfarb, a University of Washington, School of Medicine_ Nephrologist, gives context to the first clinical trial of the WAK.

 

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Active strain of wild poliovirus was detected in a water sample collected from a drain in Hyderabad | The virus emerges after 5 years.

Even with the “SWITCH” campaign going around…Poliovirus is back again… Sad!

Read about the news here.

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Novartis Biotechnology Leadership Camp 2016

The Novartis BioCamp India will be held at Hyderabad on July 17-20,2016

BioCamp is a pioneering seminar organised by Novartis that brings talented students from diverse faculties and different universities closer to the pharmaceutical industry. The programme is open to postgraduate students and young researchers in natural sciences, medicine, biotechnology, bio-informatics, pharmacy, business administration or law (specialization in Intellectual Property Rights) interested in pursuing a career in the pharmaceutical/biotechnology industry

At BioCamp, 50 students will have the opportunity to interact with leading experts in the pharmaceutical/biotech fields, learn about breakthrough medicines to address patients unmet medical needs, understand trends and challenges in the pharmaceutical sector, receive first-hand experience about starting and running a biotech company, explore career opportunities in the pharmaceutical and biotech industries and network with talented students from other universities.

Selection to BioCamp is based on academic excellence and extracurricular activities. Winning three students will be sent on an all expenses paid trip to participate at the International BioCamp taking place in Basel, Switzerland which brings together 60 selected top students from science, information technology and business universities from around the world.

The Novartis International BioCamp is a pioneering three-day seminar that brings the biotechnology sector closer to talented students from top universities around the world. Held at Novartis International Headquarters in Basel, Switzerland, the program offers participants an opportunity to:

  • Interact with key Novartis scientists who lead our unique approach to drug discovery
  • Learn about breakthrough new medicines to address patients’ unmet medical needs
  • Understand trends and challenges in the biotechnology sector
  • Receive first-hand experience about starting and running a biotech company
  • Explore career opportunities in the healthcare and biotech industries
  • Network with talented students from other countries and get in touch with Novartis associates

As the online test for the shortlisted candidates,to participate in BioCamp-India, are over and the results are awaited, we will give you a glimpse of the previous BioCamp events and also our exclusive interview with the previous winners.

For More information check their website. Also check out the BioCamp 2015 video here.

 

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Process of bacterial protein synthesis and Drugs inhibiting it | Video

Check out the video about the process of bacterial protein synthesis and drugs inhibiting it.

Tetracyclines binds to a site on 30s ribosome which is complentary to the A site in 50s. This prevents the access of incoming tRNA to the A site of the mRNA-ribosome complex.

The primary site of action of all aminoglycoside is 30s ribosomal subunit. These drugs except streptomycin, also acts on 50s and 30s-50s interface. Binding of these drugs leads to misreading of the mRNA template thereby resulting in the abnormal initiation complexes and aberrant protein formation. These abnormal initiation complexes otherwise called as Streptomycin monosomes freezes the initiation. And these aberrant proteins gets inserted into the cell membrane, leading to altered permeability which further lead to progressive disruption of the cell envelope and other vital process.

Chloramphenicol bind to a site on the 50s ribosome namely the Peptidyl Transferase Centre or PTC. This prevents the transfer of amino acid on tRNA located on P site to tRNA on A site. In short, chloramphenicol inhibits PàA transfer.

Lincosamides namely Clindamycin binds to a site very adjacent to chloramphenicol and act in a similar way to chloramphenicol.

Macrolides and Ketolides binds to a site adjacent to chloramphenicol and Lincosamides on the 50s ribosome, but has a slightly different action. The binding site of macrolide is called as Nascent Peptide Exit Tunnel or NPET. After binding to this site, macrolides constrict the exit tunnel, thereby preventing the exit of the empty tRNA after the PàA transfer. Therefore the next step being the AàP transfer cannot take place. This causes the protein synthesis machinery to stop functioning further.

Oxazolidinones namely Linezolid binds to the 23s subunit of the 50s ribosomal P-site and prevents the formation of larger ribosomal-fMet-tRNA complex and thereby inhibiting the protein synthesis at the initiation step.

 

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MD Pharmacology – A brief outline | Video

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National Treatment Guidelines for Antimicrobial Use in Infectious Diseases!

Get it here

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Dr.kartar Lalvani | Singh is King: Even at 84 | Founder – Chairman of Vitabiotics

After years of slow and steady growth, Dr Kartar Lalvani has turned Vitabiotics into a market leader. Read what he told about his journey to success!

When Dr Kartar Lalvani founded Vitabiotics in London in 1971, it was the UK’s only specialist vitamin supplement company. Today, the company produces a range of well-known brands, including Wellwoman and Omega-H3, which treat everything from mouth ulcers to menopause. The global Vitabiotics Group turns over about US$371m a year and is driven by Lalvani and his son, Tej. But it wasn’t always plain sailing for the enthusiastic and modest Sikh businessman. Indeed, the company’s roots were in adversity.

Lalvani was born in Karachi in 1931. His father was a successful pharmacist and the family lived comfortably. But in 1947, the partition of India forced them to flee to Bombay, where they had to start their lives over from nothing. Lalvani recalls it as a devastating period in his life. Aged just 16, he had to leave his secure, contented life and move to an unknown city more than 500 miles away.

In retrospect, he says that this period of turmoil was the making of him. “Without partition, perhaps my brothers and I would not have been so entrepreneurial,” he says. “But because we witnessed my father losing everything, it made us determined that such a thing would not happen to us.” This fear of failure is what drove him on in the early days and it still does, despite Vitabiotics’ current success and his own personal wealth.

In the end, Lalvani followed in his father’s footsteps and studied pharmaceutical science in London, Germany and India. But it took more than a good knowledge of the subject to succeed in the pharmaceutical sector. It was the way he applied himself to his studies, to research and then to setting up and growing the business that really made the difference.

Lalvani arrived in London in April 1956 at the end of one of the coldest winters on record. He threw himself into his studies and completed a postgraduate degree in pharmacy at King’s College London. Then came a doctorate in medical chemistry at Bonn University in West Germany.

No pain, no gain But it was a personal issue that led Lalvani into business. At that time, he suffered from mouth ulcers and had failed to find a treatment on the market that worked for him. They might alleviate the immediate pain, but they didn’t cure the problem.

So, using a combination of vitamin C and powder taken from a diarrhea tablet, Lalvani managed to treat his condition successfully. The product, called Oralcer, would be the first in his new business’s pipeline. By then, it was 1971 — and it was also where the hard work started.

There were not many young Sikh entrepreneurs in London in the 1970s, and Lalvani found it difficult to get his ulcer treatment on the shelves of the larger high-street chemists, such as Boots. He then approached the UK’s larger pharmaceutical companies, hoping to license his formula, but they too chose not to work with him.

So convinced was he that his product worked that he set up his own company, Vitabiotics. Having spent all his savings on patenting the product, however, there wasn’t enough money to launch it with much fanfare. So he began to visit individual pharmacies personally. While this approach also proved fruitless — he only managed to sell £5 worth of Oralcer — Lalvani learned a valuable lesson about getting knocked back and having answers for any questions or concerns that were thrown at him.

Perhaps just as important as Lalvani’s persistence and determination was the degree to which he was prepared to make sacrifices. He worked harder and offered a better level of service than anyone else — and learned to live on a meager budget. “I was always overworked,” he says, “but happily overworked. I’d work 17 hours a day but be happy doing it.”

This was just as well as, in addition to trying to get Oralcer to market, Lalvani was working on his next product, a multivitamin called Omega H-3. He had also taken on his first employee and was taking his first steps into marketing and PR activity. It was with Omega H-3 that Lalvani got his first big break — but it didn’t come through UK sales.

Family fortunes:
With Vitabiotics turning over hundreds of million dollars a year and Kartar Lalvani himself said to be worth £100m, you might think that would be enough success for one family. But business obviously runs in its blood. Lalvani’s brothers, Gulu and Partap, founded Binatone, which imports and distributes consumer electronics. In the 1980s, they opened offices in Spain, Japan, South Korea, Hong Kong, India, Nigeria and Taiwan. In 1989 the company was divided, with Gulu (now Chairman of Binatone Electronics International) retaining the European and Hong Kong businesses and Partap (now Chairman of Binatone Industries) retaining the group’s businesses in Eastern Europe, Africa and South Asia. Their sister, Bina, after whom Binatone was named, is a successful fashion designer in India. Kartar’s daughter is studying for a law degree and his niece, Divia Lalvani, co-owns the successful London restaurant Zuma. Kartar’s other son, Ajit, is a professor at Imperial College, London, and a leading tuberculosis specialist. In October, the Royal College of Physicians honored his research into the development of new tools for treatment and control of TB with the prestigious Weber- Parkes Trust Medal. He has developed a new test that is, according to the judges, “the first significant advance on the century-old tuberculin skin-prick test and is significantly faster and more accurate”.
Lalvani’s brothers, Gulu and Partap (see box), were also forging entrepreneurial careers. Partap was working in Nigeria, so Lalvani tried Omega H-3 there and it was a success. It was the impetus Vitabiotics needed.

But just when the time seemed right to expand, Lalvani hit a stumbling block common to all entrepreneurs: access to finance. Developing pharmaceutical products and setting up a new business isn’t cheap, but the banks wouldn’t lend to him. In fact, despite having had an account with the same bank since 1957, it wouldn’t give him a loan. While this frustrated the rate at which Vitabiotics could grow, Lalvani says the experience forced him to focus, concentrate on value for money and approach expansion and investment with caution.

Today, Vitabiotics exports to more than 100 countries and has 20 UK brands, eight of which are number one in their markets. It employs 2,200 people and has factories and offices in six countries Lalvani may have struggled to find funding at first, but turnover is now about US$371m a year, with UK sales making up about 25% of that total.

These days, Lalvani works in partnership with his son Tej. The pair, along with Vitabiotics’ Vice President and Marketing Director Robert Taylor, plan the future growth strategy of the company.

While Tej accepts that it is very much his father’s company, both father and son see the relationship as positive and say they have no difficulties separating business and family life. And both hasten to add that it wasn’t a case of Tej being given a senior position at Vitabiotics just because his father was the founder.

“I started out driving forklift trucks in a warehouse,” says Tej. “But I wanted to do it that way — it is important to understand how all the different parts of the business operate and to see how important each part is.”
Without borders stats:
As Lalvani prefers to be based in the UK, it’s down to Tej to lead the global business development of Vitabiotics. It’s a busy period in the firm’s history: it is building a new factory in Egypt, acquiring a manufacturing plant in Indonesia and looking to significantly expand its US presence. “We look at the demographics of a country, the economic fundamentals, and generally start in a new territory by working with a distributor and going from there,” says Tej. “If sales are strong.

Read more about him and vitabiotics here:

http://www.naturalproductsonline.co.uk/dr-kartar-lalvani-wins-maurice-hanssen-award-of-honour/

https://www.vitabiotics.com/ourhistory

https://www.asian-voice.com/Opinion/Columnists/Rani-Singh/Dr-Kartar-Lalvani-OBE-The-Vitamin-King-Making-People-Healthier

http://articles.economictimes.indiatimes.com/2013-03-24/news/37981375_1_nri-entrepreneur-indian-origin-entrepreneur-vitabiotics

http://www.telegraphindia.com/1110829/jsp/entertainment/story_14437516.jsp

Also read about his book: “The Making of India – The Untold story of British Enterprise”
https://books.google.co.in/books/about/The_Making_of_India.html?id=Q3_IsgEACAAJ&redir_esc=y

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Heartless human…Literally!

This is phenomenal!!
Great feat! Now the question here is wat kind of anticoagulants will be given for this patient? Check out this video.

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Streaming Full Movie The Fate of the Furious (2017) English Full Episodes Online Free Download

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Director : F. Gary Gray
Release : April 12, 2017
Language : en.
Runtime : 136 min
Genre : Action, Crime, Thriller.

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‘The Fate of the Furious’ is a movie genre Action, Crime, Thriller, was released in April 12, 2017. F. Gary Gray was directed this movie and starring by Vin Diesel. This movie tell story about When a mysterious woman seduces Dom into the world of crime and a betrayal of those closest to him, the crew face trials that will test them as never before.

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Good actionable insight for Pharma Marketers post UCPMP

482c1b35-66b3-438d-b99b-52279f466633-original

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Yet an another pioglitazone controversy!

The results of this large population based study indicate that pioglitazone is associated with an increased risk of bladder cancer. The absence of an association with rosiglitazone suggests that the increased risk is drug specific and not a class effect. Read about the study here.

Now let’s wait for the drug regulators action!!

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MaMaPrint | Segregating breast cancer patient for Chemotherapy

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A genomic test called “MaMaPrint”, by Agendia, segregates breast cancer patients whether they need chemotherapy or not. This is not a new approach. MaMaPrint got FDA approval on 2007. But scepticism among the practitioners kept it at bay. But now the American Association of Cancer Research endorsed its use at their recent meeting at New Orleans a couple a days back.

Read more about this news here. And read about “MaMaPrint” test here

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Indian CRO_Semler, Fiddle with trial data: US FDA

On April 20, 2016, the United States Food and Drug Administration’s (FDA or Agency) Notification (FDA Notification) to Pharmaceutical Companies that used Indian contract research organization (CRO) Semler Research Private Limited (Semler or Company) for conducting clinical and bioanalytical studies revealed that the studies are unacceptable due to data integrity concerns.

The FDA Notification also revealed that the Company’s bioanalytical facility was the subject of an inspection by the FDA during September 29, 2015 and October 9, 2015 that resulted in an Untitled Letter on April 19, 2016. The primary focus of the Form 483 and Untitled Letter are data integrity and controls over computer systems and records. These concerns were not limited to the FDA as the April 12, 2016 Notice of Concern (NoC) issued by the World Health Organization’s (WHO) Prequalification Team (PQT) reveals similar good clinical practices (GCP) and good laboratory practices (GLP) deficiencies.

In comparison to the FDA’s Form 483 and Untitled Letter, the WHO’s NoC identifies the products approved and pending approval under the Prequalification program that are implicated by the data integrity issues as well as alleges Semler engaged in organizational fraud at various levels of the organization

Check out these FDA notification to Pharma companies here. Also check out the FDA’s letter to Semler here. Read about the full story here.

 

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Know about your blister packs!!

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Metformin: A wonder drug

With proof of anticancer activity, metformin status has gone still up the ladder with the recent evidence of reducing the risk of adverse cardiovascular outcomes in patients with type 2 diabetes compared with sulfonylurea monotherapies. Read more about it here.

 

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Cost of medical error=Death

Medical error is the third leading cause of death in the United States, after heart disease and cancer, according to findings just published in BMJ.

Similarly, a viewpoint was just published in JAMA with the title ‘Patient Safety at the Crossroads’ regarding the same concern of medical errors.

But unfortunately, there is severe dearth of such kind of data from our country….
Also check the BMJ podcast on this.

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Pimavanserin | First drug to treat hallucinations and delusions associated with Parkinson’s disease

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World Congress on Drug discovery and Development | Nov 23-25,2016 | B’lore

Click here for registrations

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Top 25 drugs of High revenue | 2015

The prescription drugs market includes a large number of formulation products that address a diverse array of therapeutic requirements. Prescription drugs have life-cycle that is distinguished by high sales revenues during the patent-protected period. The parent companies invest in sales and marketing of the products to maximize their return on investment on research and development. The sales usually rapidly taper-off after patent expiry, as the products are exposed to competition from generics and biosimilars.

The global prescription drugs market was estimated to be USD 1,114 billion in 2015. A list of top-25 prescription drugs products based on sales revenues was collated using the reported revenues of the parent companies. These 25 drugs are marketed by 19 companies, that are the leading players in the pharmaceutical industry. The combined revenues of the top-25 drugs in this market together accounted for close to 15% of the global sales revenues of prescription drugs in 2015. Furthermore, these 25 drugs were also had a remarkably narrow scope of treatment profiles. Most drugs in the list are primarily for the treatment and management of cancer, diabetes, inflammatory disorders, and HIV or HCV infections.

Check out their list here.

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Top 10 pharma companies of world based on 2015 revenue!

Which one is your favourite? 😉

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Portable Heart in Box

Imagine a heart can be transported without stopping its beat!! Now watch this video

TransMedics Portable Heart in Box is here!!

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Watch Full Movie Online And Download Captain America: Civil War (2016)

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Language : English.
Runtime : 146 min.
Genre : Action, Science Fiction.
Stars : Chris Evans, Robert Downey Jr., Scarlett Johansson, Sebastian Stan, Anthony Mackie, Don Cheadle.

Following the events of Age of Ultron, the collective governments of the world pass an act designed to regulate all superhuman activity. This polarizes opinion amongst the Avengers, causing two factions to side with Iron Man or Captain America, which causes an epic battle between former allies.

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Update on 2013 ACCF/AHA Guideline for the Management of Heart Failure

The 2013 ACCF/AHA Guideline for the Management of Heart Failure has been updated by the American College of Cardiology/American Heart Association Task Force and Heart Failure Society of America. This focused update on new pharmacological therapy for heart failure has been based on various RCTs, that have studied the role of new drugs such as ARNI and ivabradine in patients with heart failure. The guidelines were published ahead of print in the journal Circulation, on May 20th

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Good Publishing Practices

If your are interested in publications of your research work, well here are the benefits

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Supreme Bug!

U.S. sees first case of bacteria resistant to all known antibiotics.

U.S. health officials on Thursday reported the first case in the country of a patient with an infection resistant to all known antibiotics, and expressed grave concern that the superbug could pose serious danger for routine infections if it spreads.

“We risk being in a post-antibiotic world,” said Thomas Frieden, director of the U.S. Centers for Disease Control and Prevention, referring to the urinary tract infection of a 49-year-old Pennsylvania woman who had not travelled within the prior five months.

Frieden, speaking at a National Press Club luncheon in Washington, D.C., said the infection was not controlled even by colistin, an antibiotic that is reserved for use against “nightmare bacteria.”

The infection was reported Thursday in a study appearing in Antimicrobial Agents and Chemotherapy, a publication of the American Society for Microbiology. It said the superbug itself had first been infected with a tiny piece of DNA called a plasmid, which passed along a gene called mcr-1 that confers resistance to colistin.

“(This) heralds the emergence of truly pan-drug resistant bacteria,” said the study, which was conducted by the Walter Reed National Military Medical Center. “To the best of our knowledge, this is the first report of mcr-1 in the USA.”

The study said continued surveillance to determine the true frequency of the gene in the United States is critical.

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Deep Brain Stimulation (DBS) of surgically implanted system in brain!

The video is simply amazing especially to see the eyes of that patient when his tremors got mitigated!

Not all patients are be eligible for this: only patients whose tremor & Stiffness are not controlled by drugs are the most appropriate candidates.

Eligible patients and Mechanism:
FDA gave approval for three such systems consisting of either a micro-eletrode or a pacemaker like electronic device, implanted under the skull, which blocks the electrical signals from the targeted areas in the brain such as Sub-Thalamic Nucleus (STN) & Globus Pallidus interna (GPi), a lead wire connecting the implanted device to the Neurostimulator placed near the collarbone/Chest/Abdomen under the skin.

Any of ur dearones is suffering from PD? Check out these sites:
1) http://www.dbs4pd.org/

2) http://www.parkinson.org/understanding-parkinsons/treatment/surgery-treatment-options/Deep-Brain-Stimulation

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Cipla partner Stempeutics gets DCGI nod for stem cell-based product

Cipla – Stempeutics tie up | DCGI grants limited approval for manufacturing and marketing of Stempeucel-First of kind product in India-for the treatment of Critical Limb Ischemia due to Buerger’s Disease.Watch Full Movie Streaming Online and Download

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Delhi HC reserves verdict on pleas against ban on 344 FDCs

On May a total of 334 FDC were banned by the central government. But this created a big ruffle among the practitioners. The Delhi HC kept asking the government what’s the urgency in banning these FDCs?

Recently during arguments in the HC, the drug companies had contended that government has not properly implemented the powers under section 26A (power to prohibit manufacture of drugs and cosmetics in public interest) of Drugs and Cosmetics Act under which the ban was ordered. They had also argued that the ban order was passed without considering clinical data and termed as “absurd” government’s claim that it took the decision to ban FDCs on the ground that safer alternatives were available. Thus the Delhi High Court on Thursday reserved its verdict in over 450 petitions filed by drug and healthcare majors challenging the Centre’s decision to ban 344 fixed dose combination (FDC) medicines, including well known brands like Corex cough syrup, Vicks Action 500 extra and D’Cold.

  • Read about the full report about the ban here
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Syncardia-Total artificial heart for biventricular failure | Heart on a Back pack!

Stan2 Syncardia

 

 

 

 

 

Stan Larkin – The first patient in Michigan ever discharged with a SynCardia temporary total artificial heart in 2014, underwent a traditional heart transplant 1 week ago in May 2016 at the University of Michigan Frankel Cardiovascular centre. Awesome video of Stan on youtube.

Read about the artificial heart here. Also read about the full news here

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