Monthly Archives: November 2016

Solanezumab | Tested for Alzheimer’s disease | has failed in the final phase of clinical trials

Solanezumab, has failed in the final phase of clinical trials. If it had succeeded, it had the potential to be a blockbuster drug.

Mechanism of Solanezumab

Mechanism of Solanezumab

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World Congress on Drug Discovery and Development, Nov 23-25, Bengaluru | Editor’s Review

If you were thinking that you would be attending a routine pharmacology conference, you definitely might have been either lost or stuck in awe. Because drug discovery and developement is a team work between Pharmacists, (Nano) Organic Chemists, Clinicians, medical pharmacologists, veterinarian etc. To our surprise, we a got lot more that drug discovery and development. We got to know about geriatirics and gerontology. Also about women’s health to an extent. Because this congress is a “Convention for Multidisciplinary Consortium“. It’s a conglomeration of three international conferences | World Congress on Drug Discovery and Development, World Congress on Geriatrics and Gerontology and World Congress on Gynaecology and Paediatrics  | organised by “Biogenesis Health Cluster” with the support of Govt. Of India: Department of Biotechnology-Ministry of Science and Technology, Ministry of Health, Ministry of Health and Family Welfare, Ministry of Social Justiuce and Empowerment, ICMR, Department of Pharmaceuticals-Ministry of Chemicals and Fertilizers and Indo-British Geriatrics Council.

Now thats what we call as a humongous sponsorship or support- whatever you like to name it. Pictures of Shri.Pranab Mukherjee, President of India | Shri.Narendra Modi, Prime minister of India, Shri.Siddaramaiah, Cheif Minister of Karnataka | Shri.Jagat Prakash Nadda,  Minister of Health and Family welfare | Dr.Soumya Swaminathan, Dir.Gen ICMR | Dr. G.N Singh, DCGI and many others were displayed on the home page of all the three events mentioning them as ‘Guest of Honour‘. This lured the delegates to register for the event. At the venue, only their posters were displayed and none of them came for the inaguration. Is it legitimate to display those politicians names, as “guest of honour”, who never presented themselves at the event? If the answer is yes, then next time we can expect any organising body getting funds from ICMR or DBT/DST and doing the same.

Guests of Honour who never came for the Congress

Guests of Honour who never came for the Congress

Commonly, conferences will be organised either by a national or international soceity/association or by medical colleges. It can also be from the pharmaceutical/medical device companies. This World congress was soley organised by an event management company – Biogenesis health cluster (They can also be named as a CRO as they handle various domains. Check out their home page). Their event portal page gives the details of all these conferences as a seperate  event and no where mentioning that all of those were going be conducted under the same roof. Many people were not aware of this fact. When we came to know about it a couple of days before the conference, we presumed that these events will take place in seperate halls at IISC campus. But all the three conferences were conducted in the same hall: J.N.Tata Auditorium in IISC campus.

Many were bewildered when they entered the venue until they saw two different paper presentation schedule banners and a common program schedule banner.

Day 1 started with Geriatric topics from 9 AM – 11 AM and was followed by inauguration and lunch. I must say the lunch was below average for an international event. Post lunch session was more of drug discovery and less of geriatrics.

Day 2 and day 3 had the same pattern. Day 2 had one topic on Menopause and Sexual health from the famous OG-cian & Sexologist, Dr.Padmini Prasad. Topics on pediatrics were missing.

The 60% of the talks were well delivered with an impact on the audience. Remaining 30% were average talks which bored the audience and the 10% we did not attend.

Many pharmacology PGs were not happy with the conference and were skipping the sessions. They missed many good talks. Those talks would have opened up their way of understanding research. Few note worthy ones were:

  1. Hormone imbalance are not more issues of elderly: Dr. Deepak Chathruvedi
  2. Menopause and Sexual Health: Dr. Padmini Prasad
  3. Training commnity Pharmacists on Pharmacovigilance: Dr. Pranaya Mishra
  4. Technological Advancement in Clinical Research: Dr. M.U.R Naidu | Click here to watch his presentation
  5. Falls in elderly: Dr. Sanjay Bajaj
  6. Challenges in diagnosis and mangagement of hypothensive syndromes in elderly: Dr. Kannayiram
  7. CKD- Silent killer in elderly: Dr.George Abraham
  8. Eye Examination in elderly & eye signs as presenting signs in systemic diseases: Dr.Sunil Moreker

About the selection criteria for paper / oral presentation, there wasn’t such thing. Any paper which was sent, even after the deadline for submission, | Example being my abstract acceptance | got accepted without even properly segrregating those into relevant headings. I presented a case report on “Diclofenac induced Fixed Drug Eruption” under “Clinical Research” hood which had original research paper presentations from Nano-organic chemistry, molecular docking to simple seminar topics without novel findings. Also there was no “Late Breaking abstract” submission which is a common thing in an international event (not necessarily a compulsive one). This was clearly showing the business motive of the organising company withiout giving much importance to research findings.

Pros about the conference

  • Excellent networking oppurtunity
  • Holistic approach to research
  • Good ambeince: Both in the main auditorium and paper presentation halls
  • Business perspective: Good platform to meet potential partners and investers

Cons about the conference

  • Average food for an international conference standards
  • No gala dinner
  • Varied topics clubbed for paper presentation which can not be a measuring scale for awarding best presentation
  • Many paper presentation topics were not original research but were just simple seminar topics and the presenter (Post graduate students) were trying to rush it up in 8 minutes-alloted time
  • Not providing the credit hours certificate at the venue (We were told that we will be receiving it through post)

If you check in biogenesis website, they charge annual membership subscriptions (individual-student/faculty and corporate-Emerging/Established) for availing discounts at their conferences and also to receive news letters. First time we are coming accross such business model.

From our perspective and also hearing other delegates view, this conference should have been more transparent and should have had stuck on to their theme. Merely giving half-a-day session for a theme and also providing average food, next time, when biogenesis organises a conference i doubt there will be a repeat audience. With huge support from Govt. of India (Which makes us to wonder why?), Biogenesis Healthcluster will continue their business model.

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Dynamic protocol | Android App | Editor’s Review

Ever felt the difficulty in remembering the steps to follow in a clinical trial protocol? Hope these difficulties will be solved by this android application, “Dynamic protocol” developed by a MD Pharmacology Postgraduate student at PGIMER, Chandigarh. Dr.Praveen Kumar who is from Chennai, finished his MBBS from Tanjore Medical College, Tanjore. I met him at IPSCON-2016, PGIMER, Chandigarh. It was the last day of the event (22-10-16) and as i was coming out of the food court viewing the research posters hung on the board by the presenters, i heard a bold voice explaining about a mobile application. It intrigued me. That was when i first met Dr.Praveen Kumar. He must be around 25 years old and was so vibrant in his presentation. When i suggested some edits he was too sceptical and guarded to accept it. I must even say he was hostile. *Hahaha* But i didn’t walk away as i felt he had some extraordinary stuff within him and so continued to converse with him. We discussed a lot on this and in the end we became good friends. Surprisingly he was my father’s student at Tanjore Medical College and had done General Medicine internship under his unit. Dr.Praveen explained me about the future developements and updates in the app. When I asked for  his interview on behalf of Impas Academy, he obliged to give one after updating few things in the app. Also, he is working on a project on Virtual Screening of Drugs which he is planning to present at a interational summit in the US.

Dy

Dynamic Protocol | Play Store: Android

Summary from the app page:

Problem statement

Scientist including the Biologist, Life scientist, Engineers, Neuroscientist, Physicist, Clinical Doctors, Chemist all around the world makes a lot of protocols, which are to be followed in their experiment and work. The hundreds of protocol each amounting to 10 to 30 steps need to be followed routinely. The complexity arises in the number of the factors like that of the accessibility to the protocol during the time of the experimentation, the requirement for following with the great degree of accuracy the time, temperature and much more. The researchers are routinely comfortable to the self-made protocols. Additionally, the twitching of the time and temperature need to be done in the initial time period for establishment of the protocol. This app is targeted against all these pits falls.

The app gives a rich dynamic interface for the creation, editing and most importantly for running the protocol. The app once fed with the data will help you at the time of the experimentation by describing each and every step of the protocol individually, taking care of the time pertaining to the step. The app will remind you the time when you need to change to the next step. The visual background will automatically change based on the temperature and the description of every step of the protocol will be clean and made in individual pages. The transition in the case of the timed steps will also be automatic.

The app is made in the most stable version of Android Studio (2.2) with the advanced material interface. The app is coded in the high-end JAVA(Standard edition). The app has the power to store limitless protocols (even 1 thousand) and each protocol can have 1 to 30 steps. The app also has a rich user interface.

What will be offered in the upcoming update:

Google voice to text advanced programming interface will be integrated for making entries in all the instance of the app.

Google text to speech advanced programming interface will be integrated for the run the protocol (so the app will essentially read out the protocol!!!! cool na!!!)

The option of tagging a step as the forgetful step and correspondingly you being reminded of the step by the app will be added. In addition to this, you will have the option for the deleting a protocol, deleting any step and also you can “add” additional step in the saved protocol.

You can download the app from the Google play Store by clicking here.

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ISRPTCON 2017 | 9-11 February 2017 | Government Medical College, Raigarh

The 8th  conference of Indian society of Rational therapeutics 2016-17 (ISRPTCON2017) is being hosted by the Department of Pharmacology at Late Shri Lakhiram Agrawal Memorial Government Medical College, Raigarh (Chattisgarh), India on February 9-11, 2017. The Pre-conference Workshop schedule has been organized with Four Workshop modules planned on February 9, 2017 with two parallel sessions designed for a single day.

ISRPTCON 2017 ISRPTCON 2017_2

Click here to read their Letter of Invitation.

Click here for Registration form.

Click here to view their website.

P.S: ISRPT is a society for all general practioners (MBBS/BDS/BAMS/BHMS) who are the stake holders in promoting rational therapeutics.

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National workshop on Study Designs in Clinical Trials | SRM Medical College & Hospital, Chennai | Feb 3-4, 2017 | ISCR & IMPA Supported

Department of Clinical Pharmacology & Department of Pharmacology SRM Medical College Hospital & Research Centre,Chennai in Association with Indian Society of Clinical Research (ISCR) and Indian Medical Pharmacologists Association (IMPA) will be organising a two day National workshop on Study Designs in Clinical Trials on February 3 & 4, 2017.

Topics:

Introduction to Clinical Trials,  Randomization, Blinding & Allocation concealment, Bias in clinical trials, Different study designs in clinical trials,  Superiority trials vs non-inferiority trials, Surrogate end points, Adaptive trial designs, Cross over study designs, Vaccine trial designs, Device trials.

Regisitration Details:

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Those who need Medical Council credit hours should pay additional Rs. 120 /-. Please make the Demand Draft in favor of “SRM Hospital and Research Centre”, payable at Chennai. Please complete the registration form and send to the Organizing Secretary along with DD. Those wishing to do online transfer of the registration fees, may do so, to the above mentioned account and provide the transaction ID with date of transfer in your registration form. Students/PGs should send a bonafide certificate from Head of the Department / Institution. Registration acknowledgement and other correspondences will be by e-mail only.

Registration Form:

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Get the program brochure and registration form here.

Contact Information:

Ms.Luxitaa Goenka: 9003289470
Ms. Amrita Jena: 8056121939
Landline: 044-27455826

Address for Communication: 
Dr. Melvin George
Organizing Secretary
Assistant Professor
Department of Clinical Pharmacology
SRM Medical College Hospital & Research center, Kattankalathur-603203
Mobile: 98941 33697
Email: melvin.g@ktr.srmuniv.ac.in

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