Category Archives: Regenerative Medicine

Medical Conclave on Platelet Rich Plasma (PRP) use | August 27, 2017 | IMA hall, Trichy

This is an era of regenerative therapy. As we are shifting our focus from treating the symptoms/signs of injury or disease to augmenting the natural healing/repair mechanisms, the need for proper knowledge about the regenerative therapy is of paramount importance.

For this, Mothercell Regenerative Centre (MCRC) in association with Indian Medical Pharmacologists Association (IMPA) and under the purview of IMA, Trichy Chapter is organizing a one-day Medical Conclave on Practical and Research Guidance in the use of Platelet Rich Plasma (PRP) in various specialities. As a Diabetic, Sexual Medicine and Regenerative Therapy Consultant, I will be talking on the Pharmacodynamics of PRP in Erectile Dysfunction.

You can find the details of the program and registration form here.

For online registrations, click here.

 Program schedule

One of the widely used, approved and legally accepted cell-based regenerative therapy is Platelet Rich Plasma (PRP) therapy. Let’s see some basics about platelet first.

Platelets are non-nucleated cells derived from Bone marrow megakaryocytes. The ratio of platelets to red blood cells in a healthy adult ranges from 1:10 to 1:20. It’s a biconvex structured cell which secretes various factors namely, Thromboxane A2, Platelet Derived Growth Factor (PDGF), PF4, serotonin, WBC, Phagocytic cells, fibrin matrix and unknown (growth) factors.

The main function of platelet is sealed the damaged blood vessel and provide an initial hemostatic plug (primary hemostasis) until the formation of fibrin plug (secondary hemostasis).

                                             Action of platelet in hemostasis

A concept of orthobiologics emerged in which therapeutic substances are made from naturally occurring elements in the human body which can hasten/augment the healing/regenerative process. One of such therapeutic substance is Platelet Rich Plasma (PRP), which paved way for its usage in various indicated across specialities.

Platelet Rich Plasma (PRP)

To label a product as PRP, the plasma product obtained after double centrifugation of whole blood should contain platelet 4-5 times the baseline count (1.5L – 4.5L). A normal cell ratio of platelet in plasma is 6% but PRP contains 94% platelets.

  PRP

Uses of PRP

The use of PRP is so wide, that it can be used almost in any field where the intention of healing by augmented regeneration is expected. For example, it can be used in diabetic ulcers, infertility management, skin graft failures, sealing of bleed after dental extractions, ligament/tendon/cartilage injuries. Don’t think of this as a one-stop solution or a magic remedy for any ailment. Think from this perspective: if we consider stem cells are seeds, PRP is like a fertilizer.

Fertilizer + Seed Concept

Now the quality and quantity of stem cells go down as age progress and when there is accelerated ageing (sedentary lifestyle/lack of exercise, stress, smoking, alcohol, obesity, junk food habits). In healthy young patients, PRP treatment can provide a good regenerative option. But for old age patients or ones with the above lifestyle, PRP treatment needs to be supported with autologous or allogenic stem cell treatment (MSCs preferably)

The preparation of PRP needs a dedicated centrifugation facility with a trained personnel to prepare the product which has to be utilized within a short period of time. To circumvent this problem, our regenerative therapy team, Mothercell Regenerative Centre (MCRC) from Trichy, Tamilnadu, have formulated a lyophilized allogenic PRP powder (first in India) which can be transported anywhere without stringent storage requirement and has an extended shelf life if refrigerated under recommended condition. They have applied for product patent and will be soon available for treatment after efficacy trials.

 Lyophilised PRP | Product of MCRC, Trichy

Out of all regenerative therapies, the best ones will be regular exercise, nonprocessed food with plenty of fruits and green leafy vegetables, sun exposure, lots of laughter, meditation/yoga/pranayama and ample amount of circadian sleep.

PRP pictures Courtesy: Dr Madhan Jayaraman MBBS., (MS ortho).,

MCRC Directors: Dr. V.R.Ravi MS ortho., Dr S.Sankaranarayanan MDS., Dr.K.Manimaran MDS.,

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